Perspectives on the Non-Human Primate Touch-Screen Self Ordered Spatial Search Paradigm
نویسندگان
چکیده
The self-ordered spatial search (SOSS) working memory task implemented as the computerised touch-screen task is a highly translatable platform providing a good comparison of human and non-human primate (NHP) cognitive performance measures. This communication describes how the manipulation of integral task components provides the ability to alter the dynamic range of range of performance suitable for the experimental approach being used. Accordingly, in the case of disruptors such as scopolamine for modelling cognitive decline and some aspects of brain disease states high baseline performances may be set to allow demonstration of disruption and reversal with potential new therapeutics. However, the SOSS task may be manipulated to obtain a large dynamic window of baseline performance optimised to detect the pure pro-cognitive impact of novel compounds.
منابع مشابه
Comparison of Usability of Touch-screen and Button Cell Phones Among Elderly Users
Background and Objectives: The use of new technologies, particularly mobile phones, is drastically growing on a daily basis. The usability of mobile phones can be determined for different age groups in order to reach a balanced development plan with respect to this technology. The present study aimed to investigate and compare the usability of touch-screen and button cell phones among Iranian e...
متن کاملP-50: Elongating and Elongated Spermatids Manufactured In Vitro from Non-Human Primate Pluripotent Stem Cells
Background: We have recently shown that human embryonic (hESCs) and induced pluripotent stem cells (hiPSCs) can differentiate into advanced spermatogenic cells including round spermatids by in vitro culture (Easley et al., Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Reports 2, 440-446 2012) and also, in collaboration, that rhesus spermatogonial ...
متن کاملMeasuring Attentional Biases for Threat in Children and Adults
Investigators have long been interested in the human propensity for the rapid detection of threatening stimuli. However, until recently, research in this domain has focused almost exclusively on adult participants, completely ignoring the topic of threat detection over the course of development. One of the biggest reasons for the lack of developmental work in this area is likely the absence of ...
متن کاملOrganization of working memory within the human prefrontal cortex: a PET study of self-ordered object working memory.
The prefrontal cortex plays a critical role in working memory, the active maintenance of information for brief periods of time for guiding future motor and cognitive processes. Two competing models have emerged to account for the growing human and non-human primate literature examining the functional neuroanatomy of working memory. One theory holds that the lateral frontal cortex plays a domain...
متن کاملShort-latency category specific neural responses to human faces in macaque inferotemporal cortex
In this article I would present evidence to show that timing of the flow of neural signals within the ventral visual stream is a crucial part of the neural code for categorization of faces. We recorded the activity of 554 inferotemporal neurons from two macaque monkeys performing a fixation task. More than 1000 object images including human and non-primate animal faces were presented up to 10 t...
متن کامل